Thiol reductase
WebDec 12, 2012 · Mitochondrial thiols that maintain redox reactions mainly include GSH and thioredoxin-2 (Trx2) and the associated enzymes—glutathione reductase (GR) and thioredoxin reductase (TrxR)—supporting the activities of glutathione peroxidase, glutaredoxin-2 (Grx2), and peroxiredoxin-3 (Prx3) and −5 (Prx5) (34, 70, 148). The active sites of the peroxiredoxins feature a redox-active cysteine residue (the peroxidatic cysteine), which undergoes oxidization to a sulfenic acid by the peroxide substrate. The recycling of the sulfenic acid back to a thiol is what distinguishes the three enzyme classes. 2-Cys peroxiredoxins are reduced by thiols such as thioredoxins, thioredoxin-like proteins, or possibly glutathione, whereas the 1-Cys enzymes may be reduced by ascorbic acid or glutathione in the pr…
Thiol reductase
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WebFeb 28, 2024 · Single tubs of tiny molecules (e.g., cysteine), peptides (e.g., glutathione), and thiol proteins (e.g., thioredoxin) that are not in balance and have particular oxidized/reduced ratios, making up the total thiol pool ( 13). Thiols are molecules with the sulfhydryl group-SH attached to one of their carbon atoms.
WebThioredoxin reductase (TrxR) is an NADPH-dependent, FAD-containing disulfide reductase that plays an important role in cell proliferation. 1 Unlike the well-characterized homologs … WebAug 28, 2015 · A novel thiol-reductase activity of Arabidopsis YUC6 confers drought tolerance independently of auxin biosynthesis. Nat. Commun. 6:8041 doi: …
WebAntigen presentation is a key determinant of T-cell responses. Gamma-interferon-inducible lysosomal thiol reductase (GILT) is critical for MHC class II-restricted presentation of multiple melanoma antigens to CD4+ T cells. However, GILT expression in melanoma has not been defined. WebSep 27, 2024 · Thiol peroxidase (thiol PRX) activity was spectrophotometrically monitored by NADPH consumption at 340 nm in the presence of 100 mM Tris-Cl (pH 8), 0.3 mM NADPH, 0.8 µM recombinant Arabidopsis Thioredoxin (Trx)-h2, 0.18 µM recombinant Arabidopsis NADPH-dependent Trx reductase A (NTRA), and 100 µM H 2 O 2 as described …
WebAug 28, 2024 · Thioredoxin reductase activity assay. Cells were treated with sulforaphane or vehicle for 24 h. For each treatment, 40 μg of protein was used to measure thioredoxin …
WebSep 27, 2024 · We found that an application of up to 1 µM exogenous indole-3-acetic acid (IAA) reduces Ni stress toxicity. yuc6-1D, a dominant mutant of YUC6 with high auxin levels, was more tolerant of Ni stress than wild-type (WT) … bruce j havers co incWebMar 1, 2024 · Gamma-interferon-inducible lysosomal thiol reductase (GILT) is initially discovered in the human monocytic cell line U937 and named as IP30 ( Luster et al., 1988). The precursor of GILT is a 35 kDa soluble glycoprotein and transferred to the endocytotic compartments by the mannose-6-phosphate receptor (M6PR) (Arunachalam et al., 2000 ). bruce jenner young picsWebNov 30, 2024 · Author summary Trichinella spiralis is the most important pathogen causing trichinellosis of animals and humans. Reports in mammal animals showed that gamma interferon inducible lysosomal thiol reductase (GILT) play key roles in processing and presentation of MHC class II restricted antigens. However, there were no reports about … ev rottweil stromWeba minority type of circulating T cell that expresses an antigen receptor composed of a gamma chain and a delta chin. These cells recognize different types of antigen from those recognized by alpha:beta T cells, including phosphoantigens and proteins, and are not dependent on the presentation of antigen by MHC molecules. evr phase iiWebHere, we examined whether the YUC6 thiol reductase activity also participates in the delay in senescence observed in YUC6-overexpressing (YUC6-OX) plants. YUC6 overexpression delays leaf senescence in natural … evr periyar college trichyWebJul 4, 2024 · Lysosomal reductase Gamma Interferon-Inducible Thiol Reductase (GILT) is the only identified lysosomal reductase that controls more than 11 lysosomal enzymes, and a single nucleotide polymorphism in the coding sequence of GILT has been implicated in promoting cardiovascular risk. Here, we show that GILT expression and activity are … bruce jenner wheaties box yearWebJan 18, 2000 · Whether reduction in the absence of GILT is caused by a constitutive thiol reductase is unknown. Several groups have observed that thiols activate lysosomal … bruce jenner with makeup