Hif-1 alpha protein

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August undefined, 2024

Web1 mg/mL: Formule: PBS with 0.05% sodium azide: Numéro d’ordre du gène: Q16665, Q61221, O35800: Symboles de gène(s) HIF1A: Immunogène: A fusion protein including residues 530-825 of the mouse HIF-1 alpha protein. Quantité: 100 μL: Primaire ou secondaire: Primary: Espèces cibles: Rat, Rabbit, Non-human Primate, Mouse, Human ... WebProduct Specific Information. Description: This Mgc3 monoclonal antibody detects hypoxia-inducible factor 1 alpha (HIF-1 alpha) from human, non-human primate, bovine, mouse and porcine cells. This antibody does not …

Targeting HIF-1 alpha transcriptional activity drives ... - Nature

Web5 de set. de 1997 · Findings strongly suggest that the hypoxia induced changes in HIF-1alpha stability and subsequent gene activation are mediated by redox-induced changes. The hypoxia-inducible factor 1 transcriptional activator complex (HIF-1) is involved in the activation of the erythropoietin and several other hypoxia-responsive genes. The HIF-1 … Web30 de jan. de 2003 · HIF-1 alpha stability regulation initiates a complex biological response that allows cells to act appropriately to meet patho-physiological situations of decreased … cindy mccarley designs

Tissue expression of HIF1A - Summary - The Human Protein Atlas

WebUnder hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate … Induces stabilization of the protein. 1 publication. Sequence: S → A: … We'd like to inform you that we have updated our Privacy Notice to comply … UniRef - UniProt History - UniProt External Links - UniProt Gostaríamos de exibir a descriçãoaqui, mas o site que você está não nos permite. Induces stabilization of the protein. 1 publication. Sequence: S → A: … YTH domain-containing protein 1 · Gene: YTHDC1 (KIAA1966, YT521) · Homo … WebHypoxia-inducible factor. Hypoxia-inducible factors ( HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. [1] [2] … WebNational Center for Biotechnology Information cindy mcclister marion tx

National Center for Biotechnology Information

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly ...

Web9 de abr. de 2024 · To answer to these questions, we treated epithelial HaCaT and breast cancer MCF-7 cells with different ZnO-NR concentrations. Our results showed that ZnO-NR treatments increased cell death through ROS accumulation, HIF-1α and endothelial PAS domain protein 1 (EPAS1) activation, and induction of autophagy and mitophagy in both … Web12 de abr. de 2024 · Scientific Reports - MicroRNA-142-3p promotes renal cell carcinoma progression by targeting RhoBTB3 to regulate HIF-1 signaling and GGT/GSH pathways Skip to main content Thank you for visiting ... diabetic compression socks mmhgWebThis antibody does not cross-react with ARNT or the related HIF-2 alpha. MA1-516 has been successfully used in Western blot, immunofluorescence, immunoprecipitation, immunocytochemistry, and gel shift procedures. By Western blot, this antibody detects an ∽116 kDa protein representing HIF-1 alpha after hypoxic induction in COS cells. cindy mccloud

"WebCommon gene targets for HIF-1 and HIF-2 include VEGFA and GLUT1 (5). The HIF-2 alpha subunit is rapidly targeted and degraded by the ubiquitin proteasome system under … " - Hif-1 alpha protein

Hif-1 alpha protein

Hif1a MGI Mouse Gene Detail - MGI:106918 - hypoxia inducible factor 1 ...

WebNuclear HIF-1 engages p300/CBP for binding to hypoxic response elements (HREs). This process induces transcription and regulation of genes including EPO, VEGF, iNOS2, ANGPT1 and OCT4 (4,5). Under normoxic conditions, the HIF-1 alpha subunit is rapidly targeted and degraded by the ubiquitin proteasome system. WebA loss of signal was observed for target protein in HIF-1 alpha KO cell line compared to control cell lines using ab16066. Uncharacterized bands were observed in HeLa Cas9 samples at ~40 kDa and 45 kDa. Protocols. Nuclear Extract Preparation for HIF 1 alpha. Click here to view the general protocols.

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Web8 de mai. de 2015 · Crystal Structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA. Crystal Structure of the Heterodimeric HIF-1a: ... Unique protein chains: 2; Unique … WebSummary of HIF1A (bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8) expression in human tissue. Mainly nuclear expression with cases of cytoplasmic expression. ... Hypoxia …

Webアズワンの【AXEL】84-1432-35 HIF1A (Hypoxia-inducible Factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting Protein, Basic-helix-loop-helix-PAS Protein MOP1, Class … WebProtein target information for Hypoxia-inducible factor 1-alpha (human). Find diseases associated with this biological target and compounds tested against it in bioassay …

Web4 de abr. de 2024 · HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain cd19727 Location: 13 → 83 bHLH-PAS_HIF1a_PASD8; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in hypoxia-inducible factor 1-alpha (HIF1a) and similar proteins; XM_006515478.4 → XP_006515541.1 hypoxia-inducible factor 1-alpha isoform X2. … WebThe mTOR and HIF-1 alpha protein decreased about five folds while the VEGF decreased about three folds compared with control and NC groups (P<0.05). Figure 2 Vandetanib …

WebHIF1-alpha (HIF1A) is a subunit of HIF1, which is a transcription factor found in mammalian cells cultured under reduced oxygen tension. HIF-1 is a heterodimer consisting of an alpha and beta subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors.

Webアズワンの【AXEL】84-1432-35 HIF1A (Hypoxia-inducible Factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting Protein, Basic-helix-loop-helix-PAS Protein MOP1, Class E Basic Helix-loop-helix Protein 78, bHLHe78, Member of PAS Protein 1, PAS Domain-containing Protein 8, BHLHE78, MOP1, PASD8) 200ul 140745のコーナーです。AXEL … cindy mccartyWeb9 de dez. de 2014 · HIF-1 alpha contained in a nuclear extract, binds specifically to the HIF-1 alpha response element. The HIF transcription factor complex is detected by addition of a specific primary antibody directed against HIF-1 alpha. A secondary antibody conjugated to HRP is added to provide a sensitive colorimetric readout at 450 nm. cindy mccarty hillsgrove paWeb11 de abr. de 2024 · The elevations in HIF-1α and HIF-2α protein levels indicated that hypoxia reactions were successfully induced by CoCl 2 and 1% O 2 treatment (Figure … cindy mccain contact infoWeb11 de abr. de 2024 · The elevations in HIF-1α and HIF-2α protein levels indicated that hypoxia reactions were successfully induced by CoCl 2 and 1% O 2 treatment (Figure 1C,D). ATX induction was also observed in human colon cancer DLD1 and Hela cells treated with CoCl 2 or cultured under hypoxic conditions (1% O 2 ) ( Figure S1 ). cindy mccain\u0027s son john sidney mccain ivWebHIF-1 alpha, ARNT Interacting Protein, MOP1. eCl@ss: 32160702. NACRES: NA.41. Recommended Products. Slide 1 of 10. 1 of 10. Sigma-Aldrich. H6536. Monoclonal Anti-HIF-1α antibody produced in mouse ~1 mg/mL, clone H1α67, purified immunoglobulin, buffered aqueous solution. View Price and Availability. cindy mccarty real estateWeb結構. 缺氧大部分需要氧氣呼吸的物種，都擁有保守序列HIF-1。其轉錄都有嚴格的調控機制。HIF-1是由一個α亞基和一個β亞基組成的異源蛋白二聚體，而β亞基是一種芳香烃受体核转位子（英语： Aryl hydrocarbon receptor nuclear translocator ）（ARNT）。 HIF-1屬於鹼性螺旋-環-螺旋（bHLH）家族中的PER-ARNT-SIM ... diabetic condition characterized by belchingWeb21 de jun. de 2024 · H Western-blot analysis of HIF-1α, LDHA, and Glut−1 protein expression in HIF-1α (FL) and HIF-1α (Del) B16-F10 cells cultured under normoxia (21% pO 2, N) or hypoxia (0.1% pO 2, H) conditions ... diabetic compression stockings men