WebCyproheptadine is an antiserotonin, antihistaminic compound used in adults and children to stimulate weight gain. When given to adult rats in repeated high doses, this chemical produces an inhibition of proinsulin synthesis, a reduction in … WebPharmacokinetics and Metabolism After a single 4 mg oral dose of 14 C-labelled cyproheptadine HCl in normal subjects, given as tablets, 2 to 20% of the radioactivity was excreted in the stools. Only about 34% of the stool radioactivity was unchanged drug, corresponding to less than 5.7% of the dose.
Cyproheptadine - LiverTox - NCBI Bookshelf
WebFeb 1, 1997 · Cyproheptadine, a serotonin antagonist, was originally proposed to suppress ACTH through a hypothalamic site of action ( 19 – 23 ), but may also have direct effects on ACTH-secreting tumor cells ( 12, 22, 24 – 26 ). WebCyproheptadine did not produce chromosome damage in human lymphocytes or fibroblasts in vitro ; high doses (10-4 M) were cytotoxic. Cyproheptadine did not have any … tsg technology
Antihistamines and weight gain - AAAAI
WebNov 2, 2024 · Benefits Of Cyproheptadine 1. Stimulates Appetite And Reduces Muscle Wasting Cyproheptadine has been used to increase appetite and weight gain, which may be beneficial for certain diseases … Pharmacodynamics Cyproheptadine is a very potent antihistamine or inverse agonist of the H1 receptor. At higher concentrations, it also has anticholinergic, antiserotonergic, and antidopaminergic activities. Of the serotonin receptors, it is an especially potent antagonist of the 5-HT2 receptors. This is … See more Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It was patented in … See more Adverse effects include: • Sedation and sleepiness (often transient) • Dizziness • Disturbed coordination • Confusion See more Cyproheptadine was studied in one small trial as an adjunct in people with schizophrenia whose condition was stable and were on other medication; while attention and verbal fluency appeared to be improved, the study was too small to draw … See more Cyproheptadine is used to treat allergic reactions (specifically hay fever). The evidence for its use for this purpose indicates its effectiveness but second generation … See more Cyproheptadine is a tricyclic benzocycloheptene and is closely related to pizotifen and ketotifen as well as to tricyclic antidepressants See more Cyproheptadine is used in cats as an appetite stimulant and as an adjunct in the treatment of asthma. Possible adverse effects include … See more WebJan 16, 2024 · Cyproheptadine (sye" proe hep' da deen) is a first generation antihistamine which also has anticholinergic and antiserotonergic activities that is used to treat allergic … tsg technologies inc