WebMar 17, 2024 · It can bind to its receptor, RANK, to promote osteoclast production. An increase in the OPG/RANKL ratio can increase osteoclast activity and promote bone resorption. Citation 38 CTSK is highly expressed in osteoclasts. RANKL can stimulate CTSK expression, which further enhances osteoclast activity and aggravates osteoporosis. WebCathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the CTSK gene. ... This protein, which is a member of the peptidase C1 protein family, is expressed …
Mechanical stimulation controls osteoclast function through the ...
WebNov 4, 2024 · Drug research with animal models is expensive, time-consuming and translation to clinical trials is often poor, resulting in a desire to replace, reduce, and refine the use of animal models. One approach to replace and reduce the use of animal models is to use in vitro cell-culture models. To study bone physiology, bone diseases and drugs, … WebThe protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein … dynasty warriors 5 cheats pcsx2
JCI - Osteoclast-specific cathepsin K deletion stimulates …
WebMar 31, 2024 · The completion of the differentiation of multinucleated osteoclasts is the expression of mature markers, such as cathepsin K (CTSK), MMP9, and tartrate-resistant acid phosphatase (TRAP) . CTSK is a protease that can decompose gelatin, elastin, and collagen and it plays a role in decomposing cartilage and bone in bone tissue ( 69 , 70 ). WebApr 13, 2024 · The NFATc1 is known as a master transcription regulator of osteoclast differentiation, and involved in the expression of tartrate-resistant acid phosphatase (TRAP), a typical marker protein for osteoclasts, as well as cathepsin K (CTSK), and matrix metalloproteinase-9 (MMP-9) [14, 15]. The TRAP, CTSK, and MMP-9 proteins are … WebAug 29, 2024 · Remarkably, cleavage of H3K27me3 was blocked in osteoclasts of Ctsk-/-and Ctsk-/-/Mmp9-/-mice, suggesting that Ctsk may epigenetically regulate distinctive … csail software