Cisplatin ld50 in mice

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Webcisplatin can be used to cause renal dysfunction as an approach to mimic human serum levels of renally excreted drugs. We aimed to determine the dose of cisplatin that did not affect the survival rate of mice and to achieve human-like serum concentrations of … WebAug 6, 2024 · The mice in cisplatin groups were intraperitoneally administered (2 mg/kg cisplatin dissolved in 0.9% saline) with 0.1 ml of cisplatin. The mice in the normal control (NC) group were intraperitoneally injected with physiological saline. The …

Embryotoxicity of cisplatin in rats and mice - ScienceDirect

WebMouse IP LD50 40 mg/kg No data available. Material Name: Cisplatin Injection Sodium chloride Molecular Formula: Rat Oral LD50 3000 mg/kg Mixture Mouse Oral LD50 4000 mg/kg Version: 1.0 Cisplatin Mannitol Molecular Weight: Rat Oral LD 50 13500 mg/kg Mixture Rat Oral LD 50 25.8 mg/kg WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). cms guidance on prn psychotropic medication

Pathophysiology of Cisplatin-Induced Acute Kidney Injury - Hindawi

WebMaterial Name: Cisplatin Solution for Injection - 0.5 and 1 mg/ml Revision date: 02-Jan-2007 Page 3 of 7 Version: 1.1 7. HANDLING AND STORAGE ... Rat Oral LD50 3000 mg/kg Sodium chloride Eye Irritation Rabbit Moderate Mouse Oral LD 50 4000 mg/kg Mouse Oral LD 50 32.7 mg/kg ... WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … WebThe widespread outer hair cell lesions that develop in mice treated with cisplatin plus furosemide could serve as extremely useful murine model for investigating techniques for regenerating outer hair cells, studying the mechanisms of cisplatin and furosemide … caffeine in 1 shot of coffee

Hypotonic intraperitoneal cisplatin chemotherapy for …

Cisplatin Mouse Models: Treatment, Toxicity and Translatability

WebDec 5, 2024 · Cisplatin dosage represented the mouse dose equivalent of 75 mg/m 2 IP dose in humans. Mice received 3 treatments, every 2 weeks, starting 14 days after tumor challenge. WebSep 1, 2024 · The serum of nutlin-3a or cisplatin-treated mice was obtained 4 h after LPS injection. Tissues of nutlin-3a or cisplatin-treated mice were obtained 12 h after LPS injection. Survival of mice was monitored after an i.p. injection of LPS (60 mg/kg) or E. coli (1 × 10 8 CFU). caffeine in 3rd trimesterWebJun 30, 1983 · The embryonic LD50 for mice was 5.24 mg/kg. An increase in the incidence of growth retardation or gross malformations was not discernable in the surviving fetuses with the number of dams used in this study. Cisplatin is highly embryolethal in rats and mice at dosages well below the adult therapeutic dosage in humans. cms guardrail

"WebOct 1, 2024 · In addition, significant immune cell infiltration was observed in the kidney after four doses of 9 mg/kg cisplatin, contrary to what has been previously reported. These results indicate that multiple strains of mice can be used with our repeated low-dose … " - Cisplatin ld50 in mice

Cisplatin ld50 in mice

Heterogeneity of cancer-associated fibroblasts in head and neck ...

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WebOct 6, 2014 · Synonyms Cisplatin; cis-DDP Recommended Use Laboratory chemicals. Uses advised against Food, drug, pesticide or biocidal product use. Details of the supplier of the safety data sheet Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11 Emergency Number US:001-201-796-7100 / … WebNude mice were divided into 3 groups (etoposide, cisplatin and MTX-group), 7 to 9 per group and received drug treatment which started when their tumor grew to 100 approximately 300 mm3 in volume. All drugs were intraperitoneally administrated to nude mice (each drug: 1/4 mouse LD50 dose X3, weekly).

WebObjective: The purpose of the study was to investigate the role of peroxidase V (Prx V) in Cisplatin-induced apoptosis of A549 cells and its underlying mechanism. Materials and methods: MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay was conducted to evaluate the regulatory effect of Cisplatin on the survival of A549 cells. WebSynergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity ... HCC is still a highly lethal disease. 3 Hepatic resection and liver transplantation provide good treatment that ... Kunming mice were obtained from the Animal Care Facility ...

WebMaterial Name: Cisplatin Solution for Injection - 0.5 and 1 mg/ml Trade Name: Platamine; Cisplatino; Cisplatine; Platiblastin; Plastisil; Platiblastin S Chemical Family: Mixture Intended Use: Pharmaceutical product used as Antineoplastic 2. COMPOSITION/INFORMATION … WebOct 16, 2024 · Similarly, we found that cisplatin could be safely dosed at 6 mg/kg, and that 1/3 mice lost more than 20% weight after 8 mg/kg, while …

WebAug 14, 2024 · The vehicle control mice were injected with normal saline (cisplatin group) or corn oil (AAI group). After collecting the blood and urine samples from each mouse, the levels of nephrotoxic...

WebSingle dose of cisplatin (16 mg/kg) in aging and young mice resulted in 100% mortality of 24-month-old female mice and 40% mortality of 4-8-week-old mice within 7 days after administration [148, 149]. Increased … caffeine in 2 shots espressoWebThe 50% lethal dose (LD50) of cisplatin in S3 cells was 4 x 10 (-5) M after 20 h incubation and 8.5 x 10 (-6) M after 40 h incubation. Outer medullary collecting duct (OMCD) cells were damaged 30% maximally after 20 h incubation with cisplatin, and LD50 in them became 2.5 x 10 (-5) M after 40 h incubation. cms guidance on rewards and incentivesWebProtocol (AUP). The MSDS must be attached to the AUP. 5.2. General precautions: 5.2.1. Pregnant or breast -feeding women should not work with cisplatin. 5.2.2. The following personal protective equipment mu st be worn at all times when handling cisplatin (in addition to the personal protective requirements of the animal room): 5.2.2.1. caffeine in 3 espresso shotsWebThese human neoplastic cells are also more susceptible than peripheral blood mononuclear cells (PBMCs) toward the tested compounds. Using C57BL/6 mice an LD50 of 55mgkg(-1) was determined for complex (2), suggesting that this compound is almost four times less toxic than cisplatin (LD50=14.5mgkg(-1)). caffeine in 4 lokoWebMay 1, 1996 · However, when a dose equal to one-half of the LD50 was administered in each solution to mice with i.p. tumours, survival of mice given the CDDP in hypotonic solution was significantly... cms guc loginWebApr 25, 2014 · Cisplatin (dichlorodiamino platinum) is an inorganic platinum-based chemotherapeutic agent that is widely used in the treatment of a variety of solid malignant tumors such as head and neck, lung, testis, ovarian, and bladder cancers [9]. cms guidance renal dialysis services 2022WebThe mice were sacrificed on the 35th day from the first injection. Estimation of Acute Toxicity of Polycisplatin. ICR mice (5 weeks old) weighing 20–23 g were subjected to a study to measure the lethal dose (LD 50) of Polycisplatin to compare with that of cisplatin. The mice were randomly divided into six groups with four mice each. caffeine in 32 oz sweet tea